RNA Details
Disease Name
endomyocardial fibrosis
Tissue
heart
RNA Symbol
mir-21a
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
PCR; northern blot analysis; dual-luciferase reporter assay
Target
DICER1
Pathway
TGF-BETA SIGNALING PATHWAY
PubMed ID
Title
P-SMAD2/3 and DICER promote pre-miR-21 processing during pressure overload-associated myocardial remodeling
Year
2015
Function
P-smad2/3 interacts with DICER1 to promote pre-miR-21 processing to mature miR-21.